CD274 and nonpapillary renal cell carcinoma: CRP induced the expression of both IL‐6 and PD‐L1 in HMDMs by binding to CD64, but not to CD16 or CD32 (Figures 2 and 3), indicating that the interaction of CRP with macrophage CD64 may promote the progression of ccRCC by triggering the protumor function of macrophages (Figure 6).