CRP induced the expression of both IL‐6 and PD‐L1 in HMDMs by binding to CD64, but not to CD16 or CD32 (Figures 2 and 3), indicating that the interaction of CRP with macrophage CD64 may promote the progression of ccRCC by triggering the protumor function of macrophages (Figure 6). Here, FCGR1A is linked to nonpapillary renal cell carcinoma.