An enhanced effect of CRP on both the expression of IL‐6 mRNA and the production of IL‐6 was also observed in human monocyte‐derived macrophages (HMDMs) (Figure 1f and g), whereas CRP had no direct effect on STAT3 activation in ccRCC cell lines (Supplementary figure 1b). Here, IL6 is linked to nonpapillary renal cell carcinoma.