We explored the causal relationship between LDL-C (ABCG5, ABCG8, APOB, HMGCR, LDLR, NPC1L1 and PCSK9) and TG (LPL, APOC3 and PPARA) lowering targets and AF, as well as the mediating role of circulating inflammatory factors. This evidence concerns the gene NPC1L1 and atrial fibrillation.