We explored the causal relationship between LDL-C (ABCG5, ABCG8, APOB, HMGCR, LDLR, NPC1L1 and PCSK9) and TG (LPL, APOC3 and PPARA) lowering targets and AF, as well as the mediating role of circulating inflammatory factors. Here, PPARA is linked to atrial fibrillation.