Translocation of BKCa beta subunits to the plasma membrane and interaction with BKCa alpha is a dynamically regulated process (Leo et al., 2014), which can be negatively impacted by hypertension, diabetes, and other vascular diseases (Yang et al., 2013; Nieves-Cintrón et al., 2017; Dopico et al., 2018; Peixoto-Neves and Jaggar, 2023). The gene discussed is KCNMA1; the disease is diabetes mellitus.