There are reports of more intricate karyotypes and numerous genetic abnormalities such as p16, p53, RBL2/p130, BAX, and BCL6. However, the fact that some features of this disease are similar to DLBCL may lead to unique molecular changes that affect the control of important cellular pathways, making this disease molecularly distinct. The gene discussed is CDKN2A; the disease is diffuse large B-cell lymphoma.