In a recent study, Wang et al. (Wang et al., 2024) discovered that ZDHHC5 can also catalyze the S-palmitoylation of the tumor-related protein Focal Adhesion Kinase 1 (FAK1), thereby enhancing FAK’s localization on the cell membrane and promoting epithelial-mesenchymal transition (EMT) of cells. This evidence concerns the gene ZDHHC5 and neoplasm.