Epigenome-wide association studies have explored the relationship between asthma and alterations in DNA methylation across the entire genome, pinpointing differentially methylated loci in genes such as IL-5 receptor alpha and potassium voltage-gated channel subfamily H member 2 (KCNH2) as potential biomarkers for asthma risk and targets for treatment strategies (51). This evidence concerns the gene KCNH2 and asthma.