KL and memory impairment: In many animal experiments, it has been found that the expression or supplementation of klotho will improve memory, injection of a lentiviral vector capable of delivering and maintaining klotho expression in seven-month-old mice led to a significant increase in klotho expression in the brains of mice after 3 months of feeding, and the treatment reduced memory impairment and neuronal loss (Zhou et al., 2018).