KL and Cognitive impairment: The klotho protein has long been recognized for its potential to extend lifespan and protect various organs (Kuro et al., 1997), Numerous studies have demonstrated its neuroprotective effects on the brain and nervous system, suggesting a potential role in preventing cognitive impairment.” Co-incubation of klotho with glia conditioned medium + lipopolysaccharides has shown complete restoration of low-concentration glia conditioned medium—lipopolysaccharides induced neuronal toxicity (Nakao et al., 2022).