The ECM1 protein, a non‐cellular structural component of the ECM, promotes tumor invasion and metastasis by interacting with integrin receptors or other cell membrane receptors such as moesin.[63, 64] Intriguingly, in our study, ECM1 interacted with the ENO1 receptor on the PCa cell membranes. This evidence concerns the gene ECM1 and posterior cortical atrophy.