reported that during hormonal therapy, osteoblasts mediate the formation of CRPC by regulating the production of steroids in tumor cells, promoting rapid tumor progression.[60] Our study showed that under the pressure of the AR pathway inhibitor ENZ, osteoblasts in the microenvironment of BMPC secrete ECM1 protein, which acts on tumor cells, and promotes tumor proliferation and resistance to chemotherapeutic drugs. Here, ECM1 is linked to neoplasm.