Extracellular matrix protein 1 (ECM1) was initially identified as a glycoprotein secreted by mouse osteoblasts, which participated in cell proliferation, differentiation, migration, and extracellular matrix remodeling.[18] Our study found that under the pressure of ENZ, osteoblasts increased the secretion of ECM1 protein, facilitating resistance to ENZ in PCa cells. Here, ECM1 is linked to posterior cortical atrophy.