Cancer‐associated fibroblasts (CAF) promote anti‐androgen resistance in PCa cells by secreting neuregulin 1 to initiate HER3 signaling.[13] Furthermore, ADT‐induced secreted phosphoprotein 1 (SPP1)+ myofibroblastic CAFs (myCAFs) provoke the progression of castration‐resistant PCa (CRPC) by activating the extracellular regulated protein kinases (ERK) signaling pathway.[14] Particularly, the interactions between the bone microenvironment and tumor cells have attracted considerable attention. This evidence concerns the gene SPP1 and cancer.