Although Zhang et al. did not directly demonstrate that GPX4 is transcriptionally regulated by Nrf2 in their chronic obstructive pulmonary disease study, GPX4 could play a ferroptosis-protective role as a downstream regulatory gene of Nrf2, and the inhibition of GPX4 expression could block the ferroptosis-protective effect of Nrf2 [22]. The gene discussed is GPX4; the disease is chronic obstructive pulmonary disease.