In the aspect of HDAC2, there is also consistency showing that repeated electroconvulsive seizures treatment causes the up-regulation of HDAC2 expression both at the mRNA and protein levels in the rat frontal cortex, which further reduces the histone acetylation of H3 and H4 proteins and diminishes NMDA receptor-related genes involved in the development of epilepsy [103]. The gene discussed is HDAC2; the disease is epilepsy.