ACADVL and long chain acyl-CoA dehydrogenase deficiency: As a visual demonstration, Fig. 1A shows three example genes Amacr, Pole4, and Mcrip2 detected by MICA to have concordant multi-class (WT: wild type mice; LCAD: LCAD mutated mice; VLCAD: VLCAD mutated mice) pattern across all or partial studies (tissues) (enclosed by red rectangles) while Mrpl51 is not detected due to heterogeneous patterns in all four tissues.