NCR2 and neoplasm: They include (i) Natural Killer Group 2, Member D (NKG2D), which recognizes stress-induced ligands (MICA/B, ULBPs) on tumor cells; (ii) Natural Cytotoxicity Receptors (NCRs), including NKp30, NKp44, and NKp46, which also recognize diverse ligands on tumor cells and (iii) CD16 (FcγRIII), which triggers antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc domain of opsonizing antibodies bound to tumor cells [5].