SCD and X-linked adrenoleukodystrophy: Notably, alongside increasing ABCD2 and ABCD3 [31], fibrates increase SCD1 expression through activation of peroxisome proliferator-activated receptor (PPAR) α and sterol regulatory element-binding protein (SREBP)1c [32], and therefore could represent an alternative therapeutic approach to simultaneously promote peroxisomal β-oxidation of VCLFAs and the metabolic rerouting of saturated to monounsaturated VLCFAs in X-ALD [33].