Classically activated M1 macrophages (Fig. 4A, Supplemental Table 1) and alternatively activated M2 macrophages (Fig. 4B, Supplemental Table 2) in dormant infections exhibited significant changes in genes related to macrophage polarization (FOSB, JUN), neutrophil recruitment (C1QA, C1QB, LY86, SELL, CXCL5, CCL20, CD14), immune checkpoint regulation (IFITM3, CST7), and T-cell response (VISIG4, CD28, FYN, LAT2, FCGR3A, CD52). The gene discussed is CD28; the disease is infection.