TNFRSF11B and type 2 diabetes mellitus: However, Anand et al. [42] investigated the predictive value of clinical variables, including demographic data, traditional risk factors, glycemic control status, medication use, and biomarkers such as serum high-sensitivity C-reactive protein, interleukin-6, and plasma osteoprotegerin, for CAC progression in 398 asymptomatic patients with type 2 diabetes over a mean follow-up of 2.5 ± 0.4 years.