Interestingly, treatment with LXA4 significantly attenuated the diabetes-induced increase in mFpr1 and mFpr2 expression, as well as downregulating mSaa1, consistent with the observations of Aubeux and colleagues who reported that the gene expression of FPR2 was downregulated in M2-like macrophages [38]. The gene discussed is FPR2; the disease is diabetes mellitus.