For instance, colocalizing molQTL for prioritized genes supported associations with disease categories such as EDNRA, LPA and FGF5 with cardiovascular diseases (P < 5 × 10−10), TSLP, IL33, CHRNA3, and CHRNA5 and respiratory system diseases (P < 2 × 10−16), and IL23R, TYK2, IL10 and immune system disease (P < 2 × 10−9) (Fig. 1C-D; Additional file 2: Table S4). This evidence concerns the gene CHRNA5 and cardiovascular disorder.