We also identified protective variants such as APP p.Ala673Thr (rs63750847, P = 7 × 10−11) reducing odds of developing AD [90], and ALOX15 p.Thr560Met protecting against nasal polyps (rs34210653, P = 2 × 10−15) [91]. The gene discussed is ALOX15; the disease is Nasal polyposis.