Additionally, as a key type of cell death, apoptosis induced by mitochondrial dysfunction plays an exceptional role in the progression from AKI to CKD (Aranda-Rivera et al. 2021), including tubular cell regeneration and interstitial fibrosis (Zhang et al. 2021); however, the mechanism by which FUT8 regulates this pathway is still unknown. Here, FUT8 is linked to acute kidney injury.