To examine whether mitochondrial abnormalities cause post-sepsis muscle weakness, we utilized a transgenic strain of mice overexpressing the human-derived gene for manganese superoxide dismutase (MnSOD), a mitochondria-localizing antioxidant enzyme that converts superoxide to hydrogen peroxide to be readily handled by catalase, thereby protecting mitochondria from damage (Yen et al. 1996; Holley et al. 2011; Borrelli et al. 2014; Jang et al. 2009). Here, CAT is linked to Sepsis.