Compared to the NHANES cohort, the SHeS cohort was older (mean age: 47.5 vs. 44.5 years), had a lower proportion of college education level (34.2% vs. 50.1%) and abdominal obesity (23.2% vs. 31.1%), had a higher proportion of physical activity (62.5% vs. 46.7%), had a lower level of inflammatory CRP (median CRP: 1.1 vs. 1.4 mg/L), and a relatively lower prevalence of diabetes and cardiovascular disease. The gene discussed is CRP; the disease is Abdominal obesity.