Histological analysis from five months old Tank/Azi2DKO/Ripk1KD/KD mice revealed that the skin inflammation was fully rescued by ablation of RIPK1 kinase activity, and we observed typical deposition of subdermal fat that was not distinguishable from control Azi2−/−/Ripk1KD/KD animals (Fig. 6d and Supplementary Fig. 6e). Here, RIPK1 is linked to dermatitis.