NPM1 and acute myeloid leukemia: In the interim, HCT appears to be beneficial in patients with MRD: The Acute Leukemia French Association Group provided compelling evidence that for adult patients with NPM1-mutant AML, allo HCT in first CR significantly improved both disease-free and overall survival for those with MRD (defined as less than a 4-log reduction following induction), compared to those who did not undergo allo-HCT [51].