Importantly, overexpression of MITF was able to increase proliferation in WT, confirming a direct effect of MITF on melanoma cell proliferation in SK-MEL-5, while both Rab7a and TPC2 KO lines did not show a difference in proliferation compared to empty vector expression after MITF OE, likely because MITF OE in the KOs can still not keep up with the continued degradation (Fig. S6d–h). Here, MITF is linked to melanoma.