We screened multiple human cancer cell lines including hepatocellular carcinoma (HCC; Huh7, HepG2), breast (MDA-MB-231, MCF-7, SK-BR-3), ovarian (SKOV3), cervical (HeLa), colon (Caco-2), and pancreatic (Panc-1) cancer lines as well as glioma (U87MG) and melanoma (SK-MEL-5, SK-MEL-2, SK-MEL-28, A375, SK-MEL-29, SK-MEL-19, SK-MEL-147, SK-MEL-103, UACC-62, UACC-257, MNT-1, CHL-1) lines for Rab7a mRNA expression and found particular high expression levels in the majority of melanoma lines (Fig. 1a). The gene discussed is RAB7A; the disease is cancer.