MITF and neoplasm: Mice injected with either TPC2 KO or Rab7a KO B16F10-luc cells exhibited significantly decreased tumor weights and reduced dissemination as well as reduced MITF and β-Catenin staining in ex vivo tumor tissue (Figs. 7m–o and S7j–m) compared to mice injected with WT B16F10-luc cells.