USP14 and Alzheimer disease: The important roles of USP14 in multiple diseases have encouraged the development of clinically viable USP14 antagonists, so scientists have made a lot of efforts, from covalent inhibitor to allosteric inhibitor, USP14 has become a relatively mature candidate for the development of small molecule inhibitors of AD-related DUBs, the development, structure, and optimization process of USP14 small molecule inhibitors are shown here (Fig. 3).