OAS genes inhibit virus replication through the activation of RNA cleavage pathway and have been demonstrated to enhance secretion of pro‐inflammatory cytokines in infectious disease[33] and contribute to inflammation in psoriasis.[34] Importantly, low doses of anti‐viral chloroquine decreased levels of Oas1a and Oas2 in aged rats which was accompanied by extended lifespan.[35]Oas2 was also among the genes overexpressed in the liver and kidney of older rats compared to younger rats.[36]. Here, SMOC1 is linked to psoriasis.