HSD11B1 and atherosclerosis: Of note, improved lipid metabolism has been positively linked to familial longevity.[45] Deficiency in Hsd11b1 brings about cardioprotective lipid profile in some studies whereas other studies show no modulation of atherosclerosis susceptibility upon HSD11B1 inhibition.[46] It is possible that PTS increases Hsd11b1 expression in our study primarily to suppress inflammation by acute release of glucocorticoids.