BAG3 and cancer: Another set of phosphorylation sites, including pS284, phosphothreonine(pT)285, pS289, and pS291, are not only dephosphorylated under mechanical stress (Hoffman et al, 2015; Potts et al, 2017; Ottensmeyer et al, 2024) but are also associated with cell shape remodeling (Luthold et al, 2021) and linked to BAG3 homeostasis and cancer (Kim et al, 2016; Zhou et al, 2020).