BAG3 and cancer: For instance, BAG3-phosphoserine(pS)136, as part of a 14-3-3 binding motif, is known to mediate the targeting of aggregated proteins to the aggressome (Xu et al, 2013) and has been observed to be phosphorylated during infection (Bouhaddou et al, 2020) and in cancer (Zhou et al, 2013; Mertins et al, 2016).