One notable example is APOE, which is the most prevalent high-density lipoprotein in the central nervous system (CNS) and has been consistently linked to AD in the literature (Tsai et al. 1994; Strittmatter and Roses 1995; Meyer et al. 1998; Green et al. 2009; Genin et al. 2011; Yamazaki et al. 2019). Here, APOE is linked to Alzheimer disease.