GSEA of PRS-Net-identified genes highlighted numerous immune-related pathways and the major histocompatibility complex (MHC) protein complex (Supplemental Fig. S7), agreeing well with the literature (Traugott 1987; Lee et al. 1990; Multiple Sclerosis Genetics Group et al. 1998; Dyment et al. 2005; Lincoln et al. 2005). Here, PROS1 is linked to multiple sclerosis.