The majority of the use cases were to estimate blood glucose levels (n=29, 88%), [10,27,29-31,33-38,40-48,50-53,55-58], 3 (9%) were to detect DM [10,32,54], 1 (3%) was to estimate suitable insulin doses [44], and another was to predict future blood glucose level (Table 1 and Multimedia Appendix 3 [10,27-58]). The gene discussed is INS; the disease is diabetes mellitus.