We observed a strong loss-of-fitness effect from Cis-Pt treatment across all major Fanconi Anemia pathway genes queried (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCD2, FANCI, and UBE2T) in both the RAD52WT and RAD52KO lines as compared to the Untreated screen (Fig 1D). The gene discussed is FANCC; the disease is Fanconi anemia.