Genetic studies implicated a GSA-1 –ACY-1 pathway downstream of FSHR-1 in C. elegans germline in development and fate specification, and fshr-1 acts in parallel to pmk-1 p38 Map kinase to promote resistance to pathogen infection and for expression of genes involved in innate immune responses and lipid homeostasis [27,52,53,55]. The gene discussed is FSHR; the disease is infection.