Non-structural proteins (NSP1-NSP16) encoded by the ORF1ab region of the SARS-CoV-2 genome are proteins that are not components of the virion but are transcribed and translated during host cell infection and play an important role in viral replication, translation, post-translational modification, assembly, evasion of the host immune system and other important functions [32]. This evidence concerns the gene SH2D3A and infection.