However, this target miRNA was found to be highly conserved in mice, and its degree of conservation in humans has not yet been confirmed, so further in vitro and ex vivo experiments and clinical practice are still needed to explore and validate the potential role of the miR-145a-3p/Runx2 pathway in the process of osteogenic function alteration in osteoporosis. This evidence concerns the gene RUNX2 and osteoporosis.