Interactions between CAF, tumor, and mesenchymal cells take place with the participation of exosomes, and the stimulants are transforming growth factor beta (TGF-β), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), interleukin-1 (IL-1), and interleukin-6 (IL-6) [103]. The gene discussed is IL6; the disease is neoplasm.