CD8A and cancer: To assess whether ODC1 expression is linked to changes in the immune microenvironment, we analyzed single-cell RNA-Seq data from Ruiz-Moreno et al. (33) and found that higher expression of ODC1 in cancer cells correlated with fewer CD8+ T cells in the tumor microenvironment in patients with GBM (Figure 7B), similar to what we observed in mouse models.