FGF23 and chronic kidney disease: A prior study in the Cardiovascular Health Study (CHS) showed associations between c-terminal FGF23 (cFGF23) and greater left ventricular mass and left ventricular hypertrophy, with stronger relationships in participants with CKD.18 In this study, we investigated the associations of plasma FGF23 with multiple indices of cardiac mechanics identified through 2D-STE in participants enrolled in the CHS.