Previous studies have shown that the introduction of ectopic necroptotic cells into the tumor milieu induces an antitumor response (13), but the design of the RIPK3 construct used may permit negative regulation by RIPK1 and caspase 8, which is undesirable in a safety switch context due to the risk of attenuating the necroptotic signal. This evidence concerns the gene CASP8 and neoplasm.