Similar RNA ZFP36 upregulation was observed in an independent neoadjuvant androgen deprivation therapy (ADT) study, the National Cancer Institute (NCI) dataset of paired pre- and post-treatment PCa samples treated with neoadjuvant ADT plus enzalutamide (P < 0.0001; Figure 2B). This evidence concerns the gene ZFP36 and posterior cortical atrophy.