Figure 6B provides clear validation that prostate luminal cells from mice with Ptenf/fZfp36f/f deletion do coexpress the luminal marker Krt8 with CD45. The pockets of CD45-positive PCa cells were observed to some extent in all Ptenf/fZfp36f/f tumors, in a heterogeneous manner (38-week-old tumors and ethical-endpoint tumors). These data indicate that Zfp36/ZFP36 is a critical mediator of prostate luminal cell identity. The gene discussed is KRT8; the disease is posterior cortical atrophy.