AR and posterior cortical atrophy: PCa samples from the DARANA (Dynamics of Androgen Receptor Genomics and Transcriptomics After Neoadjuvant Androgen Ablation) study (36) displayed significant upregulation of ZFP36/TTP at the protein (P < 0.0001; Figure 2A) and gene expression (P = 0.0001; Figure 2B) levels following enzalutamide treatment.