After ruling out a differential expression of HSP70 chaperone family proteins, we found that RNA-chaperone protein SERF1, known to induce misfolded protein aggregates in neurodegenerative diseases, is upregulated in the translation initiation codon ELANEmut neutrophil precursors, translocates to cytoplasm, and interacts with the truncated NE protein aggregates. Here, SERF1A is linked to neurodegenerative disease.