ELANE and severe congenital neutropenia: To study whether the ELANE translation initiation codon mutation is sufficient and necessary to induce SCN pathogenesis, we additionally generated isogenic knockin (GTG-KI) cells, where we introduced the mutation c.1A>G in healthy donor (normal) iPSCs and we corrected the mutation in GTG-P1 (SCN patient–derived iPSC line), named as the GTG-C iPSC line (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI177342DS1).