OCRL teams up with Sac2/INPP5F, a Sac1-domain containing inositol 4-phosphatase, to dephosphorylate PI(4,5)P2 akin to the dual phosphatase activities of synaptojanins (and in mice Sac2/INPP5F knock-out synergistically aggravates Synaptojannin-1-related Parkinson’s disease defects) [196, 199]. Here, SACM1L is linked to Parkinson disease.