Rabin8 activation of the Rab8 GTPase (the human homologue of yeast Sec4p) is blocked by PTEN-induced kinase 1 (PINK1), an autosomal recessive agent of Parkinson’s disease [229], suggesting a link between Parkinson’s disease and Rab8 activation by Rabin8. The gene discussed is RAB3IP; the disease is Parkinson disease.