To investigate whether reduced expression of the chosen genes occurred also in other cell types, we performed qRT-PCR analysis in HepG2 hepatoblastoma cell line with siRNA-mediated removal of TSG101 or VPS28 proteins using siTSG101#2 and siVPS28#1 (Fig. S1A) or CRISPR-Cas9-mediated knock-out of TSG101 gene (Fig. S1B–C). Here, VPS28 is linked to hepatoblastoma.