Abolished SOCE in patients with biallelic LOF variants in STIM1 or ORAI1 variably impairs T cell function, often causing early-onset CID necessitating HCT (Badran et al., 2016; Byun et al., 2010; Feske et al., 2006, 2010; Fuchs et al., 2012; Lacruz and Feske, 2015; Lian et al., 2018; McCarl et al., 2009; Picard et al., 2009; Yu et al., 2021). This evidence concerns the gene STIM1 and combined immunodeficiency.