ITPR3 and lymphopenia: Whereas our study further emphasizes that SOCE is critical for the development of unconventional T cell populations, including Treg, iNKT cells (Lian et al., 2018; Oh-Hora et al., 2013) and γδ T cells, profound lymphopenia of conventional T cells is a hallmark feature in patients with ITPR3 variants (Table 2 and Fig. 5), but not in CRAC channelopathies (Badran et al., 2016; Byun et al., 2010; Feske et al., 2006, 2010; Fuchs et al., 2012; Lacruz and Feske, 2015; Lian et al., 2018; McCarl et al., 2009; Picard et al., 2009; Schaballie et al., 2015; Yu et al., 2021).