Our findings are largely consistent with a recent study looking at the mechanism of three neuropathy-causing missense ITPR3 variants, including R2524C, demonstrating constitutive IP3R channel opening resulting in reduced ER Ca2+ stores, increased basal cytosolic Ca2+, and inappropriate SOCE when ITPR3 variants were overexpressed in TKO HEK cell lines (Terry et al., 2022). This evidence concerns the gene ITPR1 and neuropathy.