Whereas severely reduced SOCE in a patient with compound heterozygote variants in CRAC channel regulator 2 A (CRACR2A), a protein that stabilizes STIM1 and ORAI1 interactions, has been shown to underlie late-onset CID (Rice et al., 2021; Srikanth et al., 2010). Here, CRACR2A is linked to combined immunodeficiency.