The genetic analyses revealed that the G-allele of CYP2R1-rs10741657 was significantly associated with an increased risk of hyperlipidemia in both sepsis (OR = 2.333, 95% CI: 1.227–4.436, P = .010) and polytrauma groups (OR = 4.000, 95% CI: 2.048–7.811, P < .001). Here, CYP2R1 is linked to Sepsis.