Induced selective oxidative damage through Sodium Iodate (NaIO3) injection in DJ-1 knockout mice accelerated retinal atrophy, with significant downregulation of Nrf2 and increased oxidative stress in retinal cells.[45] This emphasizes the intricate interplay between oxidative stress and neurodegenerative processes in both AMD and PD. This evidence concerns the gene PARK7 and age-related macular degeneration.