The presence of the CACNA2D3 (0.938, 0.902 − 0.975, P = .001), INPP5D (0.844, 0.802 − 0.888, P < .001), RBM47 (0.937, 0.891 − 0.985, P = .011) and TBXAS1 (0.965, 0.934 − 0.998, P = .036) may be associated with a lower risk of Alzheimer’s disease. This evidence concerns the gene INPP5D and early-onset autosomal dominant Alzheimer disease.