Myo1F promotes the secretion of pro-inflammatory cytokines such as IL-1β in macrophages, contributing to epithelial damage in inflammatory conditions.[30] Myo1F expression is regulated by the integrin-αVβ3 signaling pathway, which is crucial for the differentiation and polarization of macrophages towards a pro-inflammatory M1 phenotype.[30] In a colitis model, Myo1F deficiency led to reduced secretion of pro-inflammatory cytokines, decreased epithelial damage, improved disease activity, and enhanced tissue repair. The gene discussed is IL1B; the disease is colitis.