According to previous studies, there are 5 types of MSA associated with DM, namely anti-MDA5 antibody, anti-TIF-γ antibody, anti-Mi2 antibody, anti-NXP2 antibody, and anti-SAE antibody, and each antibody has its own unique clinical characteristics.[18] Among our collected patients, 20.3% were antibody-negative, 42.3% were positive for anti-MDA5 antibodies, 16.7% were positive for anti-TIF-γ antibodies, 11.4% were positive for anti-Mi2 antibodies, 7.7% were positive for anti-NXP2 antibodies, and 1.6% were positive for anti-SAE antibodies. The gene discussed is IFIH1; the disease is diabetes mellitus.