Respiratory system involvement such as ILD (P < .001), lung infection (P < .001), respiratory symptoms (P < .001), and other systemic involvement such as: arthralgia (P < .001), and fever (P < .001) were more likely to be seen in patients with anti-MDA5 antibody, while malignancy (P < .001), and V sign (P = .017) were more likely to occur in anti-TIF1-γantibody positive patients. Here, IFIH1 is linked to interstitial lung disease.