TNF and cancer: Many studies have demonstrated that anti-TIF-γ antibodies are associated with severe rashes and malignant tumors, and their susceptibility to malignancy may be due to the fact that it is an inhibitor of tumor necrosis factor.[13,21] In our study, we found that 24.4% of anti-TIF-γ antibody-positive patients were comorbid malignant tumors, which is much higher than other types of antibodies.