The loss of the TP53 gene, which accompanies the loss of 17p, disrupts the G1/S phase checkpoint function and plays a critical role in promoting genomic instability in pPCL.[13] Nalghranyan et al[14] demonstrated that whole exome sequencing of CD138+ cells isolated from PCL patients revealed that 75% of plasma cells with TP53 copy deletion could manifest TP53 mutation. This evidence concerns the gene SDC1 and plasma cell leukemia.