Furthermore, elevated lncRNA CBR3-AS1 expression was closely correlated with larger tumor size (large vs small OR = 2.17, 95% CI: 1.50–3.14, P < .0001), lymph node metastasis (yes vs no OR = 2.75, 95% CI: 1.67–4.51, P < .0001), distant metastasis (yes vs no OR = 3.08, 95% CI: 1.82–5.23, P < .0001), and advanced tumour, node, metastasis stage (III/IV vs I/II OR = 2.82, 95% CI: 1.68–4.75, P < .0001). This evidence concerns the gene CBR3 and metastatic malignant neoplasm in the lymph nodes.