IL10 and colorectal cancer: Decrease the expression of M2-related cytokines (IL-6, IL-10, TGF-β, etc) and markers CD206, CD163, etc, thereby inducing M1-TAM polarization, inhibiting M2-TAM polarization, improving M1/M2 ratio, enhancing TAM immune function, enhancing killing activity, and finally playing antitumor immune role, inhibit the growth and metastasis of NSCLC, colorectal cancer, bladder cancer, cervical cancer, breast cancer, melanoma, etc.