IL4 and neoplasm: At this time, macrophages play an important role in tumor inhibition.[8] In the early stage of tumorigenesis, some pro-inflammatory factors in TME can promote the recruitment and polarization of M1-TAM, thus producing cytotoxic factors, phagocytosis and destruction of tumor cells, and releasing pro-inflammatory factors to exert antitumor effects.[9] The Th2 cytokines such as IL-4, IL-13, IL-10, and transforming growth factor-β (TGF-β), can induce M2-type macrophages, and M2 is mainly involved in Th2-mediated alternative response activation.