In a study of pancreatic cancer tumor cells, Wang B et al found that Osthole could reduce the expression of C/EBPB, inhibit the phosphorylation of STAT6, and thus reduce the expression of TGF-β, CCL22, CD206, CD11B, and MRC1, block the activation of M2 macrophages and inhibit the polarization of M2 macrophages. This evidence concerns the gene MRC1 and familial pancreatic carcinoma.