At the same time, the number of invasive LLC and A549 co-cultured with M1 macrophages can be directly reduced, and the proliferation and invasion of lung cancer cells can be inhibited.[43] Another study found that astragaloside can inhibit the growth and migration of liver cancer cells by regulating the TLR4/NF-κB/STAT3 signaling pathway, reducing the expression of CD206 and inhibiting the polarization of M2 macrophages.[44] Saikosaponin A is isolated from the dried roots of bupleurum, and has antitumor activity. Here, STAT3 is linked to lung cancer.