Kimura Y et al found that resveratrol can significantly inhibit the polarization and activation of M2 macrophages, thereby inhibiting the metastasis of osteosarcoma to the lung and liver and preventing the formation of lymphatic vessels.[53] In another study, Sun L et al found that resveratrol could inhibit the polarization of M2 macrophages in mice with lung cancer by reducing the activity of STAT3, thus exerting its tumor-shrinking effect on mice with lung cancer.[54] Pterostilbene is an active ingredient from rosewood, blueberry, grape and other plants. The gene discussed is STAT3; the disease is neoplasm.