M2d type is co-induced by TLR agonists and adenosine receptor agonists, and can promote tumor angiogenesis and immune escape of tumor cells through the secretion of vascular endothelial growth factor (VEGF), IL-10, TGF-β, etc, with significant pro-tumor effect.[10] Therefore, different regulatory effects on different phenotypes of M2 macrophages are the key to improving TAM ratio, enhancing TAM function and activity, and enhancing antitumor immune response. The gene discussed is VEGFA; the disease is neoplasm.