Decrease the expression of M2-related cytokines (IL-6, IL-10, TGF-β, etc) and markers CD206, CD163, etc, thereby inducing M1-TAM polarization, inhibiting M2-TAM polarization, improving M1/M2 ratio, enhancing TAM immune function, enhancing killing activity, and finally playing antitumor immune role, inhibit the growth and metastasis of NSCLC, colorectal cancer, bladder cancer, cervical cancer, breast cancer, melanoma, etc. The gene discussed is IL6; the disease is melanoma.