TBK1 and COVID-19: Myristate promotes STING-dependent autophagy degradation of interferon gene-stimulating factor/tank-binding kinase 1 complex by enhancing N-myristoylation of GTase ADP-ribosylation factor 1, thereby weakening the type I interferon (IFN) response induced by the cGAS-STING axis.[75] In addition, our results suggest an elevated risk of severe COVID-19 in individuals coinfected with SARS-CoV-2 and other pathogens.