Evidence indicates a pronounced phenomenon of emergency myelopoiesis, whereby the bone marrow mobilizes numerous immature cells in response to acute pathological injury to the organism, was observed in severe COVID-19.[25] Among them, numerous immature neutrophils expressing the inhibitory molecule programmed death ligand 1 (PD-L1) were observed to be activated.[25–28] The abnormal proliferation of bone marrow, resulting from certain pathological conditions, leads to an increase in the number of immature myeloid cells. This evidence concerns the gene CD274 and COVID-19.