YES1 and infection: In subsequent infection experiments, we detected a significant restriction for all tested variants, indicating that Yes1 is a critical host factor for the propagation of different forms and isolates of HEV (Figures 2F–H, Supplemental Figure S6A, http://links.lww.com/HC9/B60, respective full well images in Supplemental Figures S3B–D, http://links.lww.com/HC9/B60).